Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains controversial. It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 may be a key receptor for initiating microglial activation following L5 spinal nerve injury. The present studies extend this idea pharmacologically by showing that TLR4 is key for maintaining neuropathic pain following sciatic nerve chronic constriction injury. Established neuropathic pain was reversed by intrathecally delivered TLR4 receptor antagonists derived (...) from lipopolysaccharide. Additionally, -naltrexone, -naloxone, and -naloxone, which we show here to be TLR4 antagonists in vitro on both stably transfected HEK293-TLR4 and microglial cell lines, suppressed neuropathic pain with complete reversal upon chronic infusion. Immunohistochemical analyses of spinal cords following chronic infusion revealed suppression of CCI-induced microglial activation by -naloxone and -naloxone, paralleling reversal of neuropathic pain. Together, these CCI data support the conclusion that neuron-to-glia signaling through TLR4 is important not only for initiating neuropathic pain, as suggested previously, but also for maintaining established neuropathic pain. Furthermore, these studies suggest that the novel TLR4 antagonists -naloxone and -naloxone can each fully reverse established neuropathic pain upon multi-day administration. This finding with -naloxone is of potential clinical relevance. This is because -naloxone is an antagonist that is inactive at the -opioid selective receptors on neurons that produce analgesia. Thus, these data suggest that -opioid antagonists such as -naloxone may be useful clinically to suppress glial activation, yet -opioid agonists suppress pain. (shrink)

Outstanding translations by leading contemporary scholars--many commissioned especially for this volume--are presented here in the first single edition to include the entire surviving corpus of works attributed to Plato in antiquity. In his introductory essay, John Cooper explains the presentation of these works, discusses questions concerning the chronology of their composition, comments on the dialogue form in which Plato wrote, and offers guidance on approaching the reading and study of Plato's works. Also included are concise introductions by Cooper and (...) class='Hi'>Hutchinson to each translation, meticulous annotation designed to serve both scholar and general reader, and a comprehensive index. This handsome volume offers fine paper and a high-quality Smyth-sewn cloth binding in a sturdy, elegant edition. (shrink)

Cohen states in the last sentence of his book that his analysis in no way presupposes the controversial labor theory of value. For him, the contradictions of capitalist production result from the fact that its function is to create exchange value. The statements themselves and the fact that they come very late in the book illustrate two distinctive characteristics of the work. First, Cohen espouses what he calls a technological interpretation of Marx. For him, the driving force of history is (...) the steady increase in the capacity of productive forces. Capitalism supersedes feudalism because of its ability to produce more. This technological interpretation of Marx is a theory of history because only certain production relations allow for the development and expansion of productive forces. For example, the levels of production attained by capitalism would be unthinkable within the context of lord and serf. Secondly, it is not really clear that Cohen is defending a theory of history until he formulates the primacy thesis in chapter 6 and elaborates upon it and the rise of capitalism in chapter 7. The primacy thesis states that the production relations of society are explained by the level of development of its productive forces. Cohen seems to dispense with what is often thought of as the philosophy of history in his discussion of the Hegelian roots of Marxism in the first chapter. He proceeds to analyze the distinction between productive forces and production relations and its consequences for the phenomenon of fetishism in chapters 2-5. These first chapters, and some later ones as well, seem to have the property of belaboring at great length elementary problems raised by the preface to the Critique of Political Economy, and Capital as well. For example, in his distinction between productive forces and production relations, Cohen says that the two must not be confused because relations hold between objects while forces are properties of objects. He says that a soldier who guards peasants tilling the soil is not part of the labor power because he fulfills a social rather than an economic need. Then he presents and elaborates upon a list of production relations. Cohen might have avoided the need for such involved analysis if he had clearly delineated the methodological import of his work in the introduction or the first chapter. I refer to his theory of functional explanation. It is, however, only after he has discussed the problem of base and superstructure in chapter 8 that he comes to examine functional analysis in chapters 9 and 10. Since functional explanation is the crux of his defence of Marxism as a theory of history, the reader deserves a more thorough preparation for it in an introduction. (shrink)

Six essays loosely organized around varieties of interpretation and the cultural and social situations that elicit interpretation. The first essay, "Interpretation and Its Occasions," treats the nature of interpretation and its relation to the world of external reality; the pervasiveness of interpretation, even in the sciences, in contemporary intellectual life; and the necessity of interpretation in our pluralistic world. In "Style as Interpretation," Mazzeo views style, broadly defined, not so much as an esthetic matter, but as a reflection of the (...) ways people view reality. "New Wine in Old Bottles: Reflections on Historicity and the Problem of Allegory" and "The Platonic Debate over Myth, Truth, and Virtue" are "case histories" of interpretations designed to "save the texts" of the Bible and classical literature, when interpreters have recurrently found elements of these texts repugnant to their moral or philosophical ideas. "Interpretation, Humanistic Culture, and Cultural Change" draws parallels between biological and cultural evolution and focuses on the role of interpretation as a mediator between old meanings and new, between stability and innovation in a culture. In his final essay, "Myth and Science in the Theology of Rudolph Bultmann," Mazzeo discusses "the most ambitious and instructive interpretive effort of our time," Bultmann’s efforts to demythologize the Bible. (shrink)

This book of twelve essays is interdisciplinary, in the sense that it contains the lectures of experts in various disciplines—six in philosophy, three in psychology, one in electronic design and communication, one in English and American studies, and one in linguistics—all of whom focus on communication and understanding from their own perspectives.

The six essays in this book grew out of guest lectures presented during an interdisciplinary seminar at Purdue University in the spring of 1974. The authors, from departments of English, philosophy, and speech communication, share authority in the discipline of rhetoric, the unifying concept and focal point for the seminar and the book.

Fekete, describing his study as a "theoretical critique" of "modern critical theory in the Anglo-American tradition," sets out to "discover and elucidate... the historical interests" behind "bourgeois critical theory" and to show how this theory militates against human freedom. Fekete contends that modern critical theory, particularly as embodied in the work of Marshall McLuhan, has become the "theoretical face" of neocapitalism and that it has become absorbed into neocapitalist society. The Critical Twilight, designed to reveal the social causes and bias (...) of modern critical theory, grew out of the student unrest of the nineteen-sixties, when Fekete discovered the power of neocapitalist culture. (shrink)

What endogenous factors contribute to minority (Red Queen) or majority (Red King) domination under conditions of coercive bargaining? We build on previous work demonstrating minority disadvantage in non-coercive bargaining games to show that under neutral initial conditions, majorities are advantaged in high conflict situations, and minorities are advantaged in low conflict games. These effects are a function of the relationship between (1) relative proportions of the majority and minority groups and (2) costs of conflict. Although both Red King and Red (...) Queen effects can occur, we further show that agents’ increased initial propensity toward conflict advantages majorities. (shrink)

Both the recent 'Warner' review of the UK research ethics committee (REC) system and the subsequent consultation document produced by the Central Office for Research Ethics Committees (COREC) emphasize the need to distinguish 'research' from what might be termed 'non-research'. This is to be determined through a process of filtering or 'triage', the intention being that RECs will avoid considering proposals with 'no material ethical issues'. In this paper we argue that trying to distinguish 'true' research from other projects is (...) counterproductive, misleading and potentially unethical. Our case is built around three assertions: (1) the distinction between research and non-research is imprecise; (2) both medical research and non-research can generate similar ethical issues; and (3) projects should be judged according to what they involve, not how they are labelled. (shrink)

Supertasks recently discussed in the literature purport to display a failure ofenergy conservation and determinism in Newtonian mechanics. We debatewhether these supertasks are admissible as Newtonian systems, with Earmanand Norton defending the affirmative and Alper and Bridger the negative.

Costly signalling theory has become a common explanation for honest communication when interests conflict. In this paper, we provide an alternative explanation for partially honest communication that does not require significant signal costs. We show that this alternative is at least as plausible as traditional costly signalling, and we suggest a number of experiments that might be used to distinguish the two theories.

The current study collected orally-delivered autobiographical narratives from a sample of 44 undergraduate students. Participants were asked to produce both deceptive and non-deceptive versions of their narrative to two specific autobiographical question prompts while standing in front of a video camera. Narratives were then analyzed with Coh-Metrix software on 33 indices of linguistic cohesion. Following a Bonferroni correction for the large number of linguistic variables , results indicated that the deceptive narratives contained more explicit action verbs, less linguistic complexity, and (...) less referential coherence . The results support a theory that, in deceptive narratives, there is greater narrative distance between the self that narrates and the self that is narrated about. This suggests that narrative selves are constituted not as autonomous selves, but are subject to processes that are likely operating on a subconscious level. (shrink)